Nrf2 activator-7

• Description:

  Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

• UNSPSC:

  12352005

• Target:

  Keap1-Nrf2; Quinone Reductase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-7.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C (C=C1) C2=C (C3=C (C (N (S (=O) (C4=CC=C (C=C4) OC) =O) CC (O) =O) =C2) C=CC=C3) N (S (=O) (C5=CC=C (C=C5) OC) =O) CC (O) =O

• Molecular Formula:

  C35H32N2O11S2

• Molecular Weight:

  720.77

• References & Citations:

  [1]Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis (arylsulfonamido) naphthalene-N, N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2456295-39-7