Nrf2 activator-7

• Description :

  Nrf2 activator-7 (Compound 12b) is a potent Nrf2 activator and significantly activates the Nrf2 signaling pathway.

• UNSPSC :

  12352005

• Target :

  Keap1-Nrf2; Quinone Reductase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/nrf2-activator-7.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C(C=C1)C2=C(C3=C(C(N(S(=O)(C4=CC=C(C=C4)OC)=O)CC(O)=O)=C2)C=CC=C3)N(S(=O)(C5=CC=C(C=C5)OC)=O)CC(O)=O

• Molecular Formula :

  C35H32N2O11S2

• Molecular Weight :

  720.77

• References & Citations :

  [1]Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis (arylsulfonamido) naphthalene-N, N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2456295-39-7]