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Nrf2 activator-8

CAT: 0804-HY-155572Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155572Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM) . Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS) -induced neuroinflammation[1].
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nrf2-activator-8.html
Solubility
10 mM in DMSO
Smiles
O=S(/C=C/C1=NC=CC=C1Cl)(C2=NC=CC=C2OC)=O
Molecular Formula
C13H11ClN2O3S
Molecular Weight
310.76
References & Citations
[1]Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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