Nrf2 activator-8

• Description:

  Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM) . Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS) -induced neuroinflammation[1].

• UNSPSC:

  12352005

• Target:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/nrf2-activator-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(/C=C/C1=NC=CC=C1Cl)(C2=NC=CC=C2OC)=O

• Molecular Formula:

  C13H11ClN2O3S

• Molecular Weight:

  310.76

• References & Citations:

  [1]Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported