Nrf2 activator-8

• Description :

  Nrf2 activator-8 (compound 10e) is a Nrf2 activator (EC50=37.9 nM) . Nrf2 activator-8 exhibits remarkable antioxidant and anti-inflammatory effects in BV-2 microglial cells. Nrf2 activator-8 can significantly restore spatial memory deficits in a mouse model of lipopolysaccharide (LPS) -induced neuroinflammation[1].

• UNSPSC :

  12352005

• Target :

  Keap1-Nrf2

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/nrf2-activator-8.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(/C=C/C1=NC=CC=C1Cl)(C2=NC=CC=C2OC)=O

• Molecular Formula :

  C13H11ClN2O3S

• Molecular Weight :

  310.76

• References & Citations :

  [1]Kim B, et al. Optimization and evaluation of pyridinyl vinyl sulfones as Nrf2 activator for the antioxidant and anti-inflammatory effects. Eur J Med Chem. 2023 Aug 5;256:115433.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported