RIPK2/3-IN-1

• UNSPSC Description:

  RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC50 values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC50 value 14 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay[1].

• Target Antigen:

  RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ripk2-3-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OCC1=CC=C(O1)C2=CC3=C(C=C2C4=CC=CS4)C(NC5=CC(N=CS6)=C6C=C5)=NC=N3

• Molecular Weight:

  456.54

• References & Citations:

  [1]Mbilo Misehe, et al. Exploring positions 6 and 7 of a quinazoline-based scaffold leads to changes in selectivity and potency towards RIPK2/3 kinases .Eur J Med Chem. 2023 Nov 15;260:115717.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported