RIPK2/3-IN-2

• Description:

  RIPK2/3-IN-2 (29) is a dual RIPK2 and RIPK3 inhibitor, with IC50 values of 12 nM and 18 nM, respectively. RIPK2/3-IN-2 (29) induces necroptosis, with an EC50 of 0.16 μM[1].

• UNSPSC:

  12352005

• Target:

  RIP kinase

• Related Pathways:

  Apoptosis

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.67

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  FC1=C(NC2=NC=NC3=CC(C4=CC=C(N=C4)N5CCOCC5)=CC=C32)C=CC=C1

• Molecular Formula:

  C23H20FN5O

• Molecular Weight:

  401.44

• References & Citations:

  [1]Duo Ma, et al. Discovery of Potent and Balanced Dual RIPK2 and 3 Inhibitors as a New Strategy for the Treatment of Inflammatory Bowel Diseases. J Med Chem. 2025 Apr 10;68 (7) :7539-7559.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  RIPK2; RIPK3