RIPK2-IN-2

• Description :

  RIPK2-IN-2 (example 25) is a RIP2 kinase PROTAC inhibitor. RIPK2-IN-2 can block RIP2-dependent proinflammatory signaling, regulated RIP2 kinase activity in auto inflammatory diseases[1].

• UNSPSC :

  12352005

• Target :

  PROTACs; RIP kinase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PROTAC

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/ripk2-in-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(N1CCC(CC1)[C@H](NC([C@H](C)NC)=O)C(N2[C@@](C3=NC(C(C4=CC=C(C=C4)F)=O)=CS3)([H])CCC2)=O)C5=CN=C(N=C5)N(CC6)CCN6CCOC(C(S(C(C)(C)C)(=O)=O)=C7)=CC8=C7C(NC9=NNC(C)=C9C)=NC=N8

• Molecular Formula :

  C53H65FN14O7S2

• Molecular Weight :

  1093.30

• References & Citations :

  [1]Conjugates comprising ripk2 inhibitors, WO2017182418 (example 25)

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  RIPK2

• CAS Number :

  [2143956-20-9]