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RIPK2-IN-5

CAT: 0804-HY-157325-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-157325-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK2-IN-5 (compound 14) is a high affinity and excellent selectivity RIPK2 inhibitor with an IC50 value of 5.1nM. RIPK2-IN-5 has cellular anti-inflammatory effect and can reduce the secretion of MDP-induced TNF-α with a dose-dependent manner. RIPK2-IN-5 shows moderate stability in human liver microsome. RIPK2-IN-5 can be used for the research of immune diseases[1].
CAS Number
2885227-09-6
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ripk2-in-5.html
Purity
99.73
Solubility
DMSO : 116.67 mg/mL (ultrasonic)
Smiles
C12=CC(NC3=CC=NC4=CC=C(C5=CC=NC=C5)C=C34)=CC=C1SC=N2
Molecular Formula
C21H14N4S
Molecular Weight
354.43
References & Citations
[1]Fan T, et al. Design, synthesis and biological evaluation of 4-aminoquinoline derivatives as receptor-interacting protein kinase 2 (RIPK2) inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :282-293.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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