RIPK2-IN-1

• Description:

  RIPK2-IN-1 (compound 18f) is a potent RIPK2 inhibitor with an IC50 of 51 nM. RIPK2-IN-1 inhibits ALK2 with an IC50 of 5 nM. RIPK2-IN-1 has an IC50 of 390 nM on RIPK2/NOD2 in cell assay[1].

• UNSPSC:

  12352005

• Target:

  Anaplastic lymphoma kinase (ALK) ; RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ripk2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC (C2=C (N=CC (C3=CC=C (C=C3) N4CCNCC4) =C2) N) =CC (NS (C) (=O) =O) =C1

• Molecular Formula:

  C23H27N5O3S

• Molecular Weight:

  453.56

• References & Citations:

  [1]Chalada Suebsuwong, et al. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15;200:112417.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  RIPK2

• CAS Number:

  2245820-70-4