RIPK2-IN-7

CAT: 0804-HY-171592Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171592Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK2-IN-7 (Compound 10w) is an orally active, selective RIPK2 inhibitor (IC50: 0.6 nM) . RIPK2-IN-7 inhibits RIPK2 kinase activity, blocks the nucleotide-binding oligomerization domain (NOD) signaling pathway, and reduces the production of inflammatory factors (such as TNFα) . RIPK2-IN-7 can be used in the study of inflammatory bowel disease (IBD) [1].
CAS Number
[2789711-40-4]
UNSPSC
12352005
Target
NOD-like Receptor (NLR) ; RIP kinase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
NC1=C2C(C3=C(C=C(C=C3)C)F)=CN([C@H]4CC[C@H](CC4)N)C2=NC=N1
Molecular Formula
C19H22FN5
Molecular Weight
339.41
References & Citations
[1]Yuan X, et al. Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs) . J Med Chem. 2022 Jul 14;65 (13) :9312-9327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK2

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