Pyronaridine (tetraphosphate)

• Description:

  Pyronaridine tetraphosphate is an orally active Mannich base anti-malarial agent. Pyronaridine tetraphosphate is active against P. falciparum and Echinococcus granulosus infection[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection; Cancer

• Purity:

  98.79

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=C (CN2CCCC2) C=C (NC3=C4N=C (OC) C=CC4=NC5=CC (Cl) =CC=C53) C=C1CN6CCCC6.O=P (O) (O) O.O=P (O) (O) O.O=P (O) (O) O.O=P (O) (O) O

• Molecular Formula:

  C29H44ClN5O18P4

• Molecular Weight:

  910.03

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Vivas L, et al. Anti-malarial efficacy of pyronaridine and artesunate in combination in vitro and in vivo. Acta Trop. 2008 Mar;105 (3) :222-8.|[2]Jun Li, et al. Old drug repurposing for neglected disease: Pyronaridine as a promising candidate for the treatment of Echinococcus granulosus infections. EBioMedicine. 2020 Apr;54:102711.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  Plasmodium

• CAS Number:

  76748-86-2