PROTAC BTK Degrader-5

• UNSPSC Description:

  PROTAC BTK degraders-5(compound 3e) is a selective BTK PROTAC degrader with a DC50 value of 7.0 nM in JeKo-1 cells. PROTAC BTK degraders-5 has no off-target effect on degrading CRBN neosubstates. PROTAC BTK degraders-5 has anti-proliferation effect on various lymphoma tumor cells and can be used in chronic lymphoid malignancies research (Blue: E3 ligand (HY-W440230), Black: linker HY-168297；Pink:BKT inhibitor (HY-150898))1.

• Target Antigen:

  Btk; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-btk-degrader-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C(Cl)C=C(OC2=CC=CC=C2)C=C1)C3=CNC4=NC=NC(N[C@@H]5CC[C@H](NC(CC6CCN(CCC7CCN(C8=C(F)C=C(C(N(C9CCC(NC9=O)=O)C%10)=O)C%10=C8)CC7)CC6)=O)CC5)=C43

• Molecular Weight:

  958.52

• References & Citations:

  [1]Song Chen, et al. Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy. European Journal of Medicinal Chemistry.Volume 255, 5 July 2023, 115403.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported