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PROTAC BTK Degrader-13

CAT: 0804-HY-168963Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168963Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BTK Degrader-13 (Compound 25) is the PROTAC degrader for BTK with a DC50 of 0.27 μM. PROTAC BTK Degrader-13 inhibits the activity of BTK with an IC50 of 0.44 μM, inhibits IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. PROTAC BTK Degrader-13 inhibits p38 MAPK signaling pathway, block the activation of the BCR (B cell receptor) signaling pathway[1]. (Pink: ligand for target protein BTK ligand 15 ; Black: linker (HY-Y0524) ; Blue: ligand for E3 ligase cereblon (HY-103596) )
UNSPSC
12352211
Target
Btk; Itk; p38 MAPK; PROTACs
Related Pathways
MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1NC2=NC=C(C3=CC=C(OCO4)C4=C3)C=C2C15CCN(CCNC6=C7C(C(N(C8C(NC(CC8)=O)=O)C7=O)=O)=CC=C6)CC5
Molecular Formula
C33H30N6O7
Molecular Weight
622.63
References & Citations
[1]Rampeesa NK, et al., Identification of a novel Azaspirooxindolinone-based PROTAC for selective BTK degradation and enhanced anticancer activity. Bioorg Chem. 2025 Apr;157:108316.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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