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PROTAC BTK Degrader-4

CAT: 0804-HY-128408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128408Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BTK Degrader-4 (compound 15) is a potent PROTAC Bruton's tyrosine kinases (BTK) degrader (DC50 DC50 = 0.345 μM, Dmax = 27.4%) . PROTAC BTK Degrader-4 can be used for cancers, autoimmune diseases, and inflammatory diseases that are mediated by BTK[1].
CAS Number
2893795-12-3
UNSPSC
12352005
Target
Btk; PROTACs
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=NC=C(N2C[C@H](N3CCN(C)C3=O)CCC2)N=C1NC4=CC=C(C5CCN(CC6CCN(C7=CC=C(C(NC(CC8)C(NC8=O)=O)=O)N=C7)CC6)CC5)C=C4)N
Molecular Formula
C42H54N12O5
Molecular Weight
806.96
References & Citations
[1]Cristiana Guiducci, et al. Bifunctional compounds for degrading btk with diminished imid activity. WO2023287928. 2023-01-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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