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PROTAC BTK Degrader-11

CAT: 0804-HY-159947Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159947Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC BTK Degrader-11 is a PROTAC degrader that can break down BTK, with a DC50 of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research. (Pink: target protein ligand ; Black: linker; Blue: E3 ligase (HY-150839) ).
CAS Number
2736508-94-2
UNSPSC
12352005
Target
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-btk-degrader-11.html
Smiles
CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(C9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
Molecular Formula
C48H55N11O4
Molecular Weight
850.02
References & Citations
[1]Haitao Wang, et al. BGB-16673, A BTK Degrader, Overcomes On-Target Resistance From BTK Inhibitors And Present. FRANKFURT VIRTUAL. 2023. P1219.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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