PROTAC BTK Degrader-9

PROTAC BTK Degrader-9

• UNSPSC Description: PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCγ2-Ca2+-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model[1].
• Target Antigen: Btk; Nuclear Factor of activated T Cells (NFAT); PROTACs; RANKL/RANK
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;NF-κB;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-btk-degrader-9.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC(C2=NC(NC3=CN(C4CCN(CC4)CC5CCN(C6=CC=C7C(C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C6)CC5)N=C3)=NC=C2F)=CC=C1CNC(C9=CN(C(C)(C)C)N=N9)=O
• Molecular Weight: 885.99
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported