PROTAC BTK Degrader-9

• UNSPSC Description:

  PROTAC BTK Degrader-9 (compound 23) is a PROTAC degrader that effectively targets BTK. PROTAC BTK Degrader-9 downregulates the BTK-PLCγ2-Ca2+-NFATc1 signaling pathway activated by RANKL. Thus, PROTAC BTK Degrader-9 was able to inhibit osteoclastogenesis and attenuate alveolar bone resorption in a mouse periodontitis model[1].

• Target Antigen:

  Btk; Nuclear Factor of activated T Cells (NFAT); PROTACs; RANKL/RANK

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;NF-κB;PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-btk-degrader-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC(C2=NC(NC3=CN(C4CCN(CC4)CC5CCN(C6=CC=C7C(C(N(C7=O)C8C(NC(CC8)=O)=O)=O)=C6)CC5)N=C3)=NC=C2F)=CC=C1CNC(C9=CN(C(C)(C)C)N=N9)=O

• Molecular Weight:

  885.99

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported