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HDAC-IN-50

CAT: 0804-HY-152146Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152146Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-50 is a potent and orally active FGFR and HDAC dual inhibitor with IC50 values of 0.18, 1.2, 0.46, 1.4, 1.3, 1.6, 2.6, 13 nM for FGFR1, FGFR2, FGFR3, FGFR4, HDAC1, HDAC2, HDAC6, HDAC8, respectively. HDAC-IN-50 induces Apoptosis and cell cycle arrest at G0/G1 phase. HDAC-IN-50 decreases the expression of pFGFR1, pERK, pSTAT3. HDAC-IN-50 shows anti-tumor activity[1].
CAS Number
2653339-26-3
UNSPSC
12352005
Target
Apoptosis; FGFR; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-50.html
Solubility
10 mM in DMSO
Smiles
O=C(CCCCCCN1N=CC(C2=NC3=C(N=C2)C=CC(N(CCNC(C)C)C4=CC(OC)=CC(OC)=C4)=C3)=C1)NO
Molecular Formula
C31H41N7O4
Molecular Weight
575.70
References & Citations
[1]Wan G, et al. Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer. J Med Chem. 2022 Dec 22;65 (24) :16541-16569.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC6; HDAC8

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