HDAC-IN-43

• Description :

  HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].

• UNSPSC :

  12352005

• Target :

  HDAC; mTOR; PI3K

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/hdac-in-43.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NO)CCCOC1=CC=CC(C2=C3N=CN(C(C)C)C3=NC(N4CCOCC4)=N2)=C1

• Molecular Formula :

  C22H28N6O4

• Molecular Weight :

  440.50

• References & Citations :

  [1]Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8

• CAS Number :

  [1809163-24-3]