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HDAC-IN-43

CAT: 0804-HY-147966Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147966Size:1 Each
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Description
HDAC-IN-43 is a potent HDAC 1/3/6 inhibitor with IC50 values of 82, 45, and 24 nM, respectively. HDAC-IN-43 is a weak PI3K/mTOR inhibitors with IC50 values of 3.6 and 3.7 μM, respectively. HDAC-IN-43 shows broad anti-proliferative activity [1].
CAS Number
1809163-24-3
UNSPSC
12352005
Target
HDAC; mTOR; PI3K
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-43.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)CCCOC1=CC=CC(C2=C3N=CN(C(C)C)C3=NC(N4CCOCC4)=N2)=C1
Molecular Formula
C22H28N6O4
Molecular Weight
440.50
References & Citations
[1]Dizhong Chen, et al. Synthesis and biological evaluation of 6-phenylpurine linked hydroxamates as novel histone deacetylase inhibitors. Bioorg Chem. 2020 May;98:103724.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC10; HDAC11; HDAC2; HDAC3; HDAC6; HDAC8

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