HDAC-IN-46

• Target:

  Apoptosis|||Others|||HDAC

• Related Pathways:

  Chromatin/Epigenetic|||Apoptosis|||Others|||DNA Damage/DNA Repair

• Bioactivity:

  HDAC-IN-46 (compound 12c) is a potent inhibitor of HDAC, targeting HDAC1 (IC50: 0.21 ?M) and HDAC6 (IC50: 0.021 ?M) . It upregulates p-p38, downregulates Bcl-xL and cyclin D1 in MDA-MB-231 cells, blocks the cell cycle in the G2 phase, and induces apoptosis, making it useful for triple negative breast cancer (TNBC) studies.

• Smiles:

  C(C)C=1C(C2=CC=C(C=C2)C3=CN(CCCCCCCC(NO)=O)N=N3)=C(N)N=C(N)N1

• Molecular Formula:

  C22H30N8O2

• Molecular Weight:

  438.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2562386-85-8