Products for Research Use Only
RegisterLogin

HDAC-IN-73

CAT: 0804-HY-161688Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-161688Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
HDAC-IN-73 (compound P-503) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-73 shows IC50s values of 0.17, 0.49 µM for HDAC1 and HDAC6, respectively. Notably, HDAC-IN-73's inhibitory potency against HDAC6 is heightened, exhibiting a 9-fold greater efficacy than PsA (IC50=3.9 μM). HDAC-IN-73 shows potent antiproliferative activity, induces apoptosis, and causes cell cycle arrest at G2 / M phase. HDAC-IN-73 has the potential to be used for the research of cancer such as colon cancer.
CAS Number
2323571-16-8
UNSPSC
12352005
Target
Apoptosis; HDAC
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac-in-73.html
Smiles
OC1=CC=C(C/C(C(NCC[Se][Se]CCNC(/C(CC2=CC=C(O)C(Br)=C2)=N/O)=O)=O)=N\O)C=C1Br
Molecular Formula
C22H24Br2N4O6Se2
Molecular Weight
758.18
References & Citations
[1]Jiang Y, et al. Psammaplin A analogues with modified disulfide bond targeting histone deacetylases: Synthesis and biological evaluation. Eur J Med Chem. 2024 May 31;275:116541.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

Related Products

CatalogName
HY-161984HDAC-IN-76
HY-149370HDAC-IN-60
HY-142965HDAC-IN-28
HY-147892HDAC-IN-42
HY-162487HDAC-IN-72
HY-147966HDAC-IN-43
HY-18362HDAC-IN-5
HY-150597HDAC-IN-46
HY-168502HDAC-IN-81
HY-152146HDAC-IN-50

Alternative Products

CatalogName
T88120-01HDAC-IN-73
T211349-01HDAC-IN-91
T210046-01HDAC-IN-75
T205411-01HDAC-IN-85
T203306-01HDAC-IN-82
T201210-01HDAC-IN-81
T200090-01HDAC-IN-76
T62514-01HDAC-IN-46
T62072-01HDAC-IN-47
T72012-01HDAC-IN-6

Popular Products