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HDAC-IN-91

CAT: 0931-T211349-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T211349-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Carbonic Anhydrase|||Apoptosis|||PARP|||Bcl-2 Family|||Caspase|||Microtubule Associated|||HDAC
Related Pathways
Metabolism|||Cytoskeletal Signaling|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Apoptosis|||Proteases/Proteasome
Bioactivity
HDAC-IN-91 is a multi-target inhibitor affecting HDAC [HDAC1 (IC50= 134.22 nM), HDAC2 (IC50= 66.29 nM) ], carbonic anhydrase [CA IX (KI= 72.03 nM), XII (KI= 50.76 nM) ], and tubulin polymerization (IC50= 2.56 ?M) . It inhibits PARP1 and increases the Bax/Bcl-2 ratio. The compound causes cell cycle arrest at the G2/M phase and triggers apoptosis through mitochondrial pathways. By inhibiting tubulin polymerization, HDAC-IN-91 exhibits potent cytotoxic activity. This compound is applicable in research on breast cancer, colorectal cancer, cervical cancer, and lung cancer.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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