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HDAC-IN-76

CAT: 0804-HY-161984Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161984Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-76 (compound 6i) is a histone deacetylase (HDAC) inhibitor. HDAC-IN-76 IC50 values of 30 nM and 98 nM for Pf3D7 (chloroquine drug-susceptible strain) and PfDd2 (chloroquine (HY-17589A) drug-resistant strain), has a highly potent antimalarial activity against asexual blood-stage Plasmodium, respectively, and exhibits selective inhibition against parasites, with IC50 values of 7 nM and 9 nM for human HDAC1 and HDAC6, respectively, while inhibiting PfHDAC1[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Infection; Others
Assay Protocol
https://www.medchemexpress.com/hdac-in-76.html
Smiles
O=C(CN(C(C1=CN(C)C2=C1C=CC=C2)=O)CC3=CC=C(C(NO)=O)C=C3)NCC4=CC=CC=C4
Molecular Formula
C27H26N4O4
Molecular Weight
470.52
References & Citations
[1]Daniel Stopper , et al. Development of peptoid-based heteroaryl-decorated histone deacetylase (HDAC) inhibitors with dual-stage antiplasmodial activity. Eur J Med Chem. 2024 Nov 5:277:116782.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC6

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