VEGFR-2/c-Met-IN-1

• UNSPSC Description:

  VEGFR-2/c-Met-IN-1 is a dual inhibitoe of VEGFR-2 and c-Met with IC50s of 138 nM and 74 nM, respectively. VEGFR-2/c-Met-IN-1 has antitumor activity[1].

• Target Antigen:

  VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-c-met-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(O)C1=CC=C(NC(NC(C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2)=O)=S)C=C1

• Molecular Weight:

  460.46

• References & Citations:

  [1]Abdelfattah Hassan, et al. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation.Sci Rep. 2023 Oct 30;13(1):18567.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3017162-02-3