VEGFR-2/c-Met-IN-1

VEGFR-2/c-Met-IN-1

• CAS Number: 3017162-02-3
• UNSPSC Description: VEGFR-2/c-Met-IN-1 is a dual inhibitoe of VEGFR-2 and c-Met with IC50s of 138 nM and 74 nM, respectively. VEGFR-2/c-Met-IN-1 has antitumor activity[1].
• Target Antigen: VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-c-met-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)C1=CC=C(NC(NC(C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2)=O)=S)C=C1
• Molecular Weight: 460.46
• References & Citations: [1]Abdelfattah Hassan, et al. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation.Sci Rep. 2023 Oct 30;13(1):18567.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported