VEGFR-2/BRAF-IN-1

VEGFR-2/BRAF-IN-1

• UNSPSC Description: VEGFR-2/BRAF-IN-1 (Compound 4b) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.049, 0.063 and 0.005 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-1 induces apoptosis and arrests the cell cycle mainly in the G1/S phase[1].
• Target Antigen: Apoptosis; Raf; VEGFR
• Type: Reference compound
• Related Pathways: Apoptosis;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-braf-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NNC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O
• Molecular Weight: 642.50
• References & Citations: [1]Hassan RA, et al. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2022 May 10;125:105861.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported