VEGFR-2/BRAF-IN-1

• UNSPSC Description:

  VEGFR-2/BRAF-IN-1 (Compound 4b) is a dual VEGFR-2 and BRAF kinases inhibitor with IC50 values of 0.049, 0.063 and 0.005 µM against VEGFR-2, BRAFV600E and BRAFWT, respectively. VEGFR-2/BRAF-IN-1 induces apoptosis and arrests the cell cycle mainly in the G1/S phase[1].

• Target Antigen:

  Apoptosis; Raf; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-braf-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NNC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)CSC2=NC3=C(C4=C(S3)CCCC4)C(N2C5=CC=C(C=C5)Cl)=O

• Molecular Weight:

  642.50

• References & Citations:

  [1]Hassan RA, et al. Novel antiproliferative agents bearing substituted thieno[2,3-d]pyrimidine scaffold as dual VEGFR-2 and BRAF kinases inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2022 May 10;125:105861.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported