VEGFR-2/AURKA-IN-1

• UNSPSC Description:

  VEGFR-2/AURKA-IN-1 (compound 5e) is a thiazolidin-4-one derivative with antiglioma activity (IC50: 6.43 μM, LN229). VEGFR-2/AURKA-IN-1 has affinity for AURKA and VEGFR-2 and is a potential ligand. VEGFR-2/AURKA-IN-1 causes DNA strand breaks and exhibits cytotoxic and anticancer potential[1].

• Target Antigen:

  Aurora Kinase; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-aurka-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)COC1=C(C(NN2C(C3=CC=C(Cl)C=C3)SCC2=O)=O)C=C(OCC(F)(F)F)C=C1

• Molecular Weight:

  528.85

• References & Citations:

  [1]D Shankara S et al. Vetting of New 2, 5-Bis (2, 2, 2-trifluoroethoxy) Phenyl-Linked 1, 3-Thiazolidine-4-one Derivatives as AURKA and VEGFR-2 Inhibitor Antiglioma Agents Assisted with In Vitro and In Silico Studies[J]. ACS Omega, 2023.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported