VEGFR-2/InhA-IN-1

• UNSPSC Description:

  VEGFR-2/InhA-IN-1 is a pyrazole-based dual inhibitor of InhA-VEGFR with anti-tuberculosis and anti-angiogenic activities. VEGFR-2/InhA-IN-1 has good antibacterial activity against Mycobacterium tuberculosis H37Rv strain (MIC=6.25 μg/mL) and significantly inhibits VEGFR-2 (IC50=15.27 nM)[1].

• Target Antigen:

  Bacterial; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Protein Tyrosine Kinase/RTK

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-inha-in-1.html

• Smiles:

  O=C(NC1=CC=C(F)C=C1)NC2=CN(C3=CC=CC=C3)N=C2C4=CC=C(Cl)C=C4

• Molecular Weight:

  406.84

• References & Citations:

  [1]Shaaban, et al. "The first-in-class pyrazole-based dual InhA-VEGFR inhibitors towards integrated antitubercular host-directed therapy." Bioorganic Chemistry 145 (2024): 107179.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported