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VEGFR-2/Flk-1

CAT: 0209-103-PA18SSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-103-PA18SSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The antibody recognizes mouse vascular endothelial growth factor receptor 2, alos known as CD309, VEGFR2, KDR, protein tyrosine kinase receptor flk-1, and fetal liver kinase-1. Flk-1 is a member of the tyrosine protein kinase family, sub-family CSF-1/PDGF, that contains a single pass transmembrane receptor with a protein kinase domain and seven immunoglobulin-like domains in the extracellular region. Flk-1 is expressed at high levels in adult heart, lung, kidney, brain, and skeletal muscle; other tissues express at lower levels. Flk-1 is a receptor for VEGF-A or fully processed VEGF-C; ligand binding plays a key role in vascular development and vascular permeability.
Synonyms
Soluble vascular endothelial growth factor receptor-2 ; sKdr; sLy73; sFlk-1; sVEGFR2; sVEGF receptor 2; skinase insert domain protein receptor
NCBI Gene ID
16542
UniProt
P35918
Accession Number
ACJ66293.1
Accession Number mRNA
EU884114
Chromosomal Location
5 C3.3; 5 42.0 cM
Reactivity
Anti-Mouse
Cross Reactivity
Mouse
Target Antigen
Recombinant mouse esFlk-1 (RT Cat# S01-M04)
Clone
Rabbit IgG
Applications
WB
Purification Method
Protein A purified
Assay Protocol
Centrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml.
Bioactivity
Western Blot: use at 1-5 µg/ml.
Form
Lyophilized
Buffer
PBS
Reconstitution
Water
Storage Conditions
The lyophilized antibody is stable for at least 2 years at -20°C. After sterile reconstitution the antibody is stable at 2-8°C for up to 6 months. Frozen aliquots are stable for at least 6 months when stored at -20°C. Addition of a carrier protein or 50% glycerol is recommended for frozen aliquots.
Host or Source
Rabbit

UniProtKB · P35918

Vascular endothelial growth factor receptor 2

VGFR2_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
P35918
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Kdr
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
VEGFR-2
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
C5H7S5, Q8VCD0
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisDifferentiation

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell junctionCell membraneCytoplasmCytoplasmic vesicleEndoplasmic reticulumEndosomeMembraneNucleusSecreted

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Technical term

Reference proteome

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AR31161PU-NCD309 / VEGFR-2 / Flk-1 (esKDR) Mouse Protein
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