VEGFR-2/AKT-IN-1

• UNSPSC Description:

  VEGFR-2/AKT-IN-1 (compound 17) is a dual inhibitor of VEGFR-2 and AKT, with the IC50s of 0.164 μM and 0.452 μM, respectively. VEGFR-2/AKT-IN-1 has antitumor activity[1].

• Target Antigen:

  Akt; VEGFR

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-akt-in-1.html

• Smiles:

  NC1=C(C2=NN=C(NC(C3=CC=CC=C3)=O)S2)SC4=C1C5=NC(N)=NN5C=N4

• Molecular Weight:

  409.45

• References & Citations:

  [1]Heba K Abd El-Mawgoud, et al. Design, synthesis and cytotoxic evaluation of new thieno[2,3-d]pyrimidine analogues as VEGFR-2/AKT dual inhibitors, apoptosis and autophagy inducers. Bioorg Chem. 2024 Sep:150:107622.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported