VEGFR-2/c-Met-IN-2

• UNSPSC Description:

  VEGFR-2/c-Met-IN-2 (compound 3e) is a VEGFR-2/c-Met inhibitor, with IC50 values of 83 and 48 nM, respectively. VEGFR-2/c-Met-IN-2 exhibits cytotoxic activity against HCT-116 cell line (IC50: 3.403 µM)[1].

• Target Antigen:

  c-Met/HGFR; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/vegfr-2-c-met-in-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC(NC1=CC=C(Cl)C=C1)=S)C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2

• Molecular Weight:

  450.90

• References & Citations:

  [1]Hassan A, et al. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation. Sci Rep. 2023 Oct 30;13(1):18567.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3017162-04-5