VEGFR-2/c-Met-IN-2

VEGFR-2/c-Met-IN-2

• CAS Number: 3017162-04-5
• UNSPSC Description: VEGFR-2/c-Met-IN-2 (compound 3e) is a VEGFR-2/c-Met inhibitor, with IC50 values of 83 and 48 nM, respectively. VEGFR-2/c-Met-IN-2 exhibits cytotoxic activity against HCT-116 cell line (IC50: 3.403 µM)[1].
• Target Antigen: c-Met/HGFR; VEGFR
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-c-met-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NC(NC1=CC=C(Cl)C=C1)=S)C2=CC=C(N3C(NC4=C(C=CC=C4)C3=O)=O)C=C2
• Molecular Weight: 450.90
• References & Citations: [1]Hassan A, et al. Novel 3-phenylquinazolin-2,4(1H,3H)-diones as dual VEGFR-2/c-Met-TK inhibitors: design, synthesis, and biological evaluation. Sci Rep. 2023 Oct 30;13(1):18567.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported