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C-Met-IN-2

CAT: 0804-HY-101773Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101773Size:1 Each
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Description
C-Met-IN-2 is a potent, selective and orally available c-Met inhibitor, with an IC50 of 0.6 nM, with antitumor activity.
CAS Number
1635406-73-3
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-Met-IN-2.html
Solubility
10 mM in DMSO
Smiles
OCCN1N=CC(C2=CN=C3C(N(C(C4=C(F)C=C(N=CC(C5=CN(C)N=C5)=C6)C6=C4)C)N=N3)=N2)=C1
Molecular Formula
C24H21FN10O
Molecular Weight
484.49
References & Citations
[1]Zhao F, et al. Identification of 3-substituted-6- (1- (1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl) ethyl) quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization. Eur J Med Chem. 2017 Jul 7;134:147-158.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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