Keap1-Nrf2-IN-15

Keap1-Nrf2-IN-15

• CAS Number: 2456295-45-5
• UNSPSC Description: Keap1-Nrf2-IN-15 (Compound 24a) is a potent Keap1-Nrf2 protein-protein interaction inhibitor with IC50s of 77 nM and 2.5 nM in FP assay and TR-FRET assay, respectively[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-15.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C(C=C1)S(=O)(N(C2=CC(CCCN3C(C4=C(C3=O)C=CC=C4)=O)=C(C5=CC=CC=C52)N(S(=O)(C6=CC=C(C=C6)OC)=O)CC(O)=O)CC(O)=O)=O
• Molecular Weight: 801.84
• References & Citations: [1]Abed DA, et al. Optimization of the C2 substituents on the 1,4-bis(arylsulfonamido)naphthalene-N,N'-diacetic acid scaffold for better inhibition of Keap1-Nrf2 protein-protein interaction. Eur J Med Chem. 2023 Apr 5;252:115302.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported