ERα degrader 6

• UNSPSC Description:

  ERα degrader 6 (Compound 31q) is an ERα degrader (KI: 75 nM). ERα degrader 6 also inhibits ARO with an IC50 of 37.7 nM. ERα degrader 6 inhibits tumor growth in MCF-7 tumor xenograft model. ERα degrader 6 can be used for breast cancer research[1].

• Target Antigen:

  Cytochrome P450; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S([C@@H]1[C@H]2C(C3=CC=C(N4C=NC=N4)C=C3)=C(C5=CC=C(O)C=C5)[C@H](O2)C1)(N(CC(F)(F)F)C6=CC=CC=C6)=O

• Molecular Weight:

  568.57

• References & Citations:

  [1]Xin L, et al. Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur J Med Chem. 2023 May 5;253:115328.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2775441-10-4