ERα degrader 6

ERα degrader 6

• CAS Number: 2775441-10-4
• UNSPSC Description: ERα degrader 6 (Compound 31q) is an ERα degrader (KI: 75 nM). ERα degrader 6 also inhibits ARO with an IC50 of 37.7 nM. ERα degrader 6 inhibits tumor growth in MCF-7 tumor xenograft model. ERα degrader 6 can be used for breast cancer research[1].
• Target Antigen: Cytochrome P450; Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erα-degrader-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=S([C@@H]1[C@H]2C(C3=CC=C(N4C=NC=N4)C=C3)=C(C5=CC=C(O)C=C5)[C@H](O2)C1)(N(CC(F)(F)F)C6=CC=CC=C6)=O
• Molecular Weight: 568.57
• References & Citations: [1]Xin L, et al. Structure-guided identification of novel dual-targeting estrogen receptor α degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer. Eur J Med Chem. 2023 May 5;253:115328.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported