ERα degrader 10

• UNSPSC Description:

  ERα degrader 10 is a selective and orally active estrogen receptor α (ERα) degrader. ERα degrader 10 exhibits potent ERα binding affinity (IC50 of 24.0 nM) and degradation ability (EC50 of 5.3 nM). ERα degrader 10 degrades ERα through the proteasome-mediated pathway. ERα degrader 10 can be used for the study of breast cancer[1].

• Target Antigen:

  Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/erα-degrader-10.html

• Smiles:

  O=C(O)/C=C/C1=CC=C(/C(C2=CC=C(C3=CN(C)N=C3)C=C2)=C(C4=CC=CC=C4Cl)/CC)C=C1

• Molecular Weight:

  468.97

• References & Citations:

  [1]Rupeng Dai, et al. Drug discovery of N-methyl-pyrazole derivatives as potent selective estrogen receptor degrader (SERD) for the treatment of breast cancer. Eur J Med Chem. 2024 Sep 23:279:116894.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported