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PDE4-IN-10

CAT: 0804-HY-147950Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147950Size:1 Each
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Description
PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].
CAS Number
2413564-66-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE) ; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-10.html
Solubility
10 mM in DMSO
Smiles
CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14
Molecular Formula
C18H13N
Molecular Weight
243.30
References & Citations
[1]Bta B, et al. Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor - ScienceDirect. Bioorganic Chemistry. April 2020;97:103691.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4; TNFRSF5/CD40

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