PDE4-IN-10

• Description:

  PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE) ; TNF Receptor

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pde4-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14

• Molecular Formula:

  C18H13N

• Molecular Weight:

  243.30

• References & Citations:

  [1]Bta B, et al. Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor - ScienceDirect. Bioorganic Chemistry. April 2020;97:103691.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE4; TNFRSF5/CD40

• CAS Number:

  2413564-66-4