PDE4-IN-10

PDE4-IN-10

• CAS Number: 2413564-66-4
• UNSPSC Description: PDE4-IN-10 (compound 7a) is a potent PDE4 inhibitor, with an IC50 of 7.01 μM for PDE4B. PDE4-IN-10 shows selectivity, microsomal stability, inhibition of TNF-α and no major toxicities in vitro[1].
• Target Antigen: Phosphodiesterase (PDE); TNF Receptor
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-10.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=CC2=C3C=CC=CC3=CN=C2C4=CC=CC=C14
• Molecular Weight: 243.30
• References & Citations: [1]Bta B, et al. Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor - ScienceDirect. Bioorganic Chemistry. April 2020;97:103691.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported