PDE4-IN-9

• Description:

  PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pde4-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=CC=C(C=C1)C2=NC(C(N3CCS/C3=N\C#N)=O)=CO2

• Molecular Formula:

  C15H12N4O3S

• Molecular Weight:

  328.35

• References & Citations:

  [1]Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE4

• CAS Number:

  2519450-32-7