PDE4-IN-9

PDE4-IN-9

• CAS Number: 2519450-32-7
• UNSPSC Description: PDE4-IN-9 (Compound 5j) is a potent inhibitor of PDE4. PDE4-IN-9 exhibits lower IC50 value (1.4 μM) against PDE4 than parent rolipram (2.0 μM) in in vitro enzyme assay. PDE4-IN-9 also displays good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC=C(C=C1)C2=NC(C(N3CCS/C3=N\C#N)=O)=CO2
• Molecular Weight: 328.35
• References & Citations: [1]Lin Y, et al. Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors. Eur J Med Chem. 2020 Dec 1;207:112795.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported