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DPP-4-IN-17

CAT: 0804-HY-175590Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175590Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DPP-4-IN-17 is an orally active and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with an IC50 value of 0.12 nM. DPP-4-IN-17 increases the enzyme's Km value (75.73 μM vs. 27.18 μM of substrate alone) and reduces catalytic efficiency. DPP-4-IN-17 reduces blood glucose levels and reverses weight loss in Streptozotocin (STZ) /Nicotinamide (NA) (HY-B0150) -induced diabetic rats. DPP-4-IN-17 can be used for the study of type 2 diabetes mellitus (T2DM).
UNSPSC
12352100
Target
Dipeptidyl Peptidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
COC([C@@H]1CCCN1C([C@@H](NC([C@@H]2CCCN2C(OC(C)(C)C)=O)=O)CCCCNC([C@@H]3CCCN3C(OC(C)(C)C)=O)=O)=O)=O
Molecular Formula
C32H53N5O9
Molecular Weight
651.79
References & Citations
[1]Jaglan S, et al. Rationally designed small peptides targeting DPP-4: Identification of potent anti-diabetic agents. Bioorg Chem. 2025 Aug;163:108781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4

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