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DPP-4/GPR119 modulator 2

CAT: 0804-HY-146469Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146469Size:1 Each
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Description
DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research[1]. DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
2010927-65-6
UNSPSC
12352005
Target
Dipeptidyl Peptidase; GPR119
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/dpp-4-gpr119-modulator-2.html
Solubility
10 mM in DMSO
Smiles
CC#CCN1C(N2CCC[C@H](C2)N)=NC3=C1C(N(C(N3C)=O)CCCN4CCC(CC4)C(NC5=CC=CC=C5)=O)=O
Molecular Formula
C30H40N8O3
Molecular Weight
560.69
References & Citations
[1]Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DPP-4

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