DPP-4/GPR119 modulator 2

• Description:

  DPP-4/GPR119 modulator 2 (Compound 20i) is a dipeptidyl peptidase IV (DPP-IV) inhibitor and GPR119 agonist with an IC50 of 0.22 μM for DPP-IV and an EC50 of 0.95 μM for GPR119. DPP-4/GPR119 modulator 2 can be used for diabetes research[1]. DPP-4/GPR119 modulator 2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• UNSPSC:

  12352005

• Target:

  Dipeptidyl Peptidase; GPR119

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/dpp-4-gpr119-modulator-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC#CCN1C (N2CCC[C@H] (C2) N) =NC3=C1C (N (C (N3C) =O) CCCN4CCC (CC4) C (NC5=CC=CC=C5) =O) =O

• Molecular Formula:

  C30H40N8O3

• Molecular Weight:

  560.69

• References & Citations:

  [1]Li G, et al. The optimization of xanthine derivatives leading to HBK001 hydrochloride as a potent dual ligand targeting DPP-IV and GPR119. Eur J Med Chem. 2020 Feb 15;188:112017.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  DPP-4

• CAS Number:

  2010927-65-6