PCSK9 modulator-4

• Description :

  PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C) . PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].

• UNSPSC :

  12352005

• Target :

  PCSK9

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pcsk9-modulator-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CNC2=C1C=CC=C2F)C3=NC4=CC=C(F)C=C4N3C

• Molecular Formula :

  C17H11F2N3O

• Molecular Weight :

  311.29

• References & Citations :

  [1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2476490-20-5]