PCSK9 modulator-4

• UNSPSC Description:

  PCSK9 modulator-4 (Compound 21) is a potent modulator of PCSK9 with an EC50 value of 0.15 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C). PCSK9 modulator-4 has the potential for the research of hyperlipidemia[1].

• Target Antigen:

  PCSK9

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pcsk9-modulator-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CNC2=C1C=CC=C2F)C3=NC4=CC=C(F)C=C4N3C

• Molecular Weight:

  311.29

• References & Citations:

  [1] Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2476490-20-5