PCSK9 modulator-2

• Description :

  PCSK9 modulator-2 (Compound 1) is a potent modulator of PCSK9 with an EC50 value of 202 nM. PCSK9 is a recently validated target for lowering low-density lipoprotein cholesterol (LDL-C) . PCSK9 modulator-2 has the potential for the research of hyperlipidemia[1].

• UNSPSC :

  12352005

• Target :

  PCSK9

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pcsk9-modulator-2.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=CC2=C1NC=C2CC3=CC4=CC(F)=CC=C4N3

• Molecular Formula :

  C17H12F2N2

• Molecular Weight :

  282.29

• References & Citations :

  [1]Xie H, et al. From methylene bridged diindole to carbonyl linked benzimidazoleindole: Development of potent and metabolically stable PCSK9 modulators. Eur J Med Chem. 2020 Nov 15;206:112678.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2365416-53-9]