11β-HSD1-IN-6

11β-HSD1-IN-6

• CAS Number: 1303515-33-4
• UNSPSC Description: 11β-HSD1-IN-6 is a an 11β-HSD-1 inhibitor. The 11β hydroxysteroid dehydrogenase enzymes (11β-HSDs) mediate the interconversion of the glucocorticoid (GC) corticosterone or cortisol to an inactive form, 11-dehydrocorticosterone (11-DHC) or Cortisone, respectively[1].
• Target Antigen: 11β-HSD
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/11β-hsd1-in-6.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=CC=C(N=CN2)C2=C1)N3[C@]4([H])[C@@](CCC3)([H])C5=CC(C#N)=CC=C5C4.Cl
• Molecular Weight: 378.85
• References & Citations: [1]Bo Qu, et al. Large-Scale Enantioselective Reduction of 2,3-Disubstituted Indenopyridine Enables a Practical Manufacturing Process for an 11β-HSD-1 Inhibitor. Org. Process Res. Dev. 2022, 26(3):963–975.
• Shipping Conditions: Room temperature
• Clinical Information: Phase 2