11β-HSD1-IN-15
CAT:
804-HY-14156
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
11β-HSD1-IN-15
- CAS Number: 946398-78-3
- UNSPSC Description: 11β-HSD1-IN-15 is an inhibitor of 11β-hydroxysteroid dehydrogenase type I (11β-HSD1). 11β-HSD1-IN-15 blocks the conversion of corticosterone to cortisol by binding to the active site of the 11β-HSD1 enzyme. 11β-HSD1-IN-15 can be used to investigate the role of 11β-HSD1 enzymes IN the development of metabolic syndrome, obesity, cognitive decline and type 2 diabetes[1].
- Target Antigen: 11β-HSD
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-protein/nucleotide metabolism
- Field of Research: Metabolic Disease
- Assay Protocol: https://www.medchemexpress.com/11β-hsd1-in-15.html
- Smiles: FC(F)(C1=C(N2C[C@H](N(CC2)S(=O)(C3=C(C=C(C=C3)C(N)=O)Cl)=O)C)C=CC(F)=C1)F
- Molecular Weight: 479.88
- References & Citations: [1]Wan Z K, et al. Efficacious 11β-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model[J]. Journal of medicinal chemistry, 2009, 52(17): 5449-5461.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported