11β-HSD1-IN-9

11β-HSD1-IN-9

• CAS Number: 88283-34-5
• UNSPSC Description: 11β-HSD1-IN-9 (compound c4a) is a potent 11β-HSD1 inhibitor with IC50 values of 0.48 and 1.3 µM for human and murine 11β-HSD1, respectively. 11β-HSD1-IN-9 competitively interacts with rat 11β-HSD1. 11β-HSD1-IN-19 can be used in studies of obesity, hyperglycemia and cognitive impairment[1].
• Target Antigen: 11β-HSD
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/11β-hsd1-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: C1=C(C=CC(=C1)C(F)(F)F)C(=O)CC2=CN=CC=N2
• Molecular Weight: 266.22
• References & Citations: [1]Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported