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11β-HSD1-IN-24

CAT: 0804-HY-178691Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178691Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
11β-HSD1-IN-24 (Compound 10l) is a potent and selective 11β-HSD1 inhibitor with an IC50 of 0.5 nM. 11β-HSD1-IN-24 can effectively block the conversion of inactive Cortisone to active Cortisol (HY-N0583). 11β-HSD1-IN-24 can be used for the research of metabolic disease, such as type 2 diabetes[1].
CAS Number
1009373-58-3
UNSPSC
12352005
Target
11β-HSD
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C(CC1C2=C(C3(C1)CCN(CC3)C(NC4C5CC6CC(CC4C6)C5)=O)C(Br)=CC=C2)O
Molecular Formula
C26H33BrN2O3
Molecular Weight
501.46
References & Citations
[1]Tice C M, et al. Spirocyclic ureas: orally bioavailable 11β-HSD1 inhibitors identified by computer-aided drug design[J]. Bioorganic & medicinal chemistry letters, 2010, 20 (3) : 881-886.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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