11β-HSD1-IN-10

• UNSPSC Description:

  11β-HSD1-IN-10 (compound c3a) is a potent 11β-HSD1 inhibitor (IC50=1.8 µM for human). 11β-HSD1-IN-10 can be used in studies of obesity, hyperglycemia and cognitive impairment[1].

• Target Antigen:

  11β-HSD

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/11β-hsd1-in-10.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C1=CC=C2C(=C1)N=C(CC(=O)C3=CC(=CC=C3)C(F)(F)F)O2

• Molecular Weight:

  305.25

• References & Citations:

  [1]Naredo-Gonzalez G, et al. Non-invasive in vivo assessment of 11β-hydroxysteroid dehydrogenase type 1 activity by 19F-Magnetic Resonance Spectroscopy. Sci Rep. 2022 Sep 29;12(1):16268.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  849021-37-0