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Pparδ agonist 5

CAT: 0804-HY-141494Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-141494Size:1 Each
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Description
Pparδ agonist 5, an orally active PPARδ-selective agonist (EC50=0.335 μM), is much greater than that of the prototypical standard GW0742. Pparδ agonist 5 promotes improvements in bone density and microarchitecture in vivo[1].
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pparδ-agonist-5.html
Solubility
10 mM in DMSO
Smiles
OC(/C=C/C1=CC=C(N(C)CC2=C(C)N=C(C3=CC=C(C(F)(F)F)C=C3)S2)C=C1C)=O
Molecular Formula
C23H21F3N2O2S
Molecular Weight
446.49
References & Citations
[1]Kress BJ, et al. Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis. J Med Chem. 2021;64 (10) :6996-7032.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARδ

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