PPARγ agonist 17

CAT: 0804-HY-173166Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173166Size:1 Each
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Description
PPARγ agonist 17 (Compound C1) is a PPARγ agonist. PPARγ agonist 17 enhances PPARγ activity and blocks the cell cycle in G2/M phase, inhibits cell migration and induces apoptosis in HT-29 cells. PPARγ agonist 17 has a broad spectrum anti-proliferative activity in cancer cells with relatively low toxicity in normal cells which cannot cross the blood-brain barrier[1].
CAS Number
[3054652-58-0]
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
C[C@]12[C@@](C(C=C3[C@]2(CC[C@@]4([C@@]3([H])C[C@](CC4)(C(O)=O)C)C)C)=O)([H])[C@@]5([C@@](C(C)([C@H](CC5)OC(CC6=CC=CC(NC(COC7=C(C)C=CC(C)=C7)=O)=C6)=O)C)([H])CC1)C
Molecular Formula
C48H63NO7
Molecular Weight
766.02
References & Citations
[1]Lin H, et al. Design, synthesis and antitumor activity evaluation of novel modified 18β-glycyrrhetinate derivatives as PPARγ agonists. Bioorg Chem. 2025 Apr;157:108307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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