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PPARα/δ agonist 2

CAT: 0804-HY-162123Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162123Size:1 Each
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Description
PPARα/δ agonist 2 (compound 14) is a potent PPARα and PPARδ agonist with EC50s of 3255 nM and 1475 nM for human PPARα and PPARβ/δ, respectively. PPARα/δ agonist 2 shows anti-inflammatory effects[1].
UNSPSC
12352005
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pparα-γ-agonist-4.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(COC2=CC(CCC(C)(CC/C=C(C)/CC/C=N/NC3=NC=C(Cl)C=C3C(F)(F)F)O4)=C4C=C2)C=C1
Molecular Formula
C31H32ClF4N3O2
Molecular Weight
590.05
References & Citations
[1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages. Eur J Med Chem. 2024 Jan 4;265:116125.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARβ/δ

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