PPARα/δ agonist 2

• UNSPSC Description:

  PPARα/δ agonist 2 (compound 14) is a potent PPARα and PPARδ agonist with EC50s of 3255 nM and 1475 nM for human PPARα and PPARβ/δ, respectively. PPARα/δ agonist 2 shows anti-inflammatory effects[1].

• Target Antigen:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pparα-γ-agonist-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC1=CC=C(COC2=CC(CCC(C)(CC/C=C(C)/CC/C=N/NC3=NC=C(Cl)C=C3C(F)(F)F)O4)=C4C=C2)C=C1

• Molecular Weight:

  590.05

• References & Citations:

  [1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages. Eur J Med Chem. 2024 Jan 4;265:116125.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported