PPARα/δ agonist 2

• Description :

  PPARα/δ agonist 2 (compound 14) is a potent PPARα and PPARδ agonist with EC50s of 3255 nM and 1475 nM for human PPARα and PPARβ/δ, respectively. PPARα/δ agonist 2 shows anti-inflammatory effects[1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pparα-γ-agonist-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  FC1=CC=C(COC2=CC(CCC(C)(CC/C=C(C)/CC/C=N/NC3=NC=C(Cl)C=C3C(F)(F)F)O4)=C4C=C2)C=C1

• Molecular Formula :

  C31H32ClF4N3O2

• Molecular Weight :

  590.05

• References & Citations :

  [1]García A, et al. Benzopyran hydrazones with dual PPARα/γ or PPARα/δ agonism and an anti-inflammatory effect on human THP-1 macrophages. Eur J Med Chem. 2024 Jan 4;265:116125.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARα; PPARβ/δ