PPARα agonist 2

• UNSPSC Description:

  PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].

• Target Antigen:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/pparα-agonist-2.html

• Smiles:

  O=C(O)C1=CC=CC(NCC2=CC=C(OCC3=CC=C(F)C=C3)C(C)=C2)=C1

• Molecular Weight:

  365.40

• References & Citations:

  [1]Xiaozheng Dou, et al. Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. J Med Chem. 2020 Mar 26;63(6):2854-2876.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2376590-40-6