PPARα agonist 2

• Description :

  PPARα agonist 2 (compound 4u) is a potent and selective PPARα agonist with an EC50 of 37 nM. PPARα agonist 2 exhibits >2,700-fold selectivity for PPARα over other PPAR isoforms. PPARα agonist 2 has the potential for retinal disorders research[1].

• CAS Number :

  [2376590-40-6]

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pparα-agonist-2.html

• Purity :

  98.9

• Smiles :

  O=C(O)C1=CC=CC(NCC2=CC=C(OCC3=CC=C(F)C=C3)C(C)=C2)=C1

• Molecular Formula :

  C22H20FNO3

• Molecular Weight :

  365.40

• References & Citations :

  [1]Xiaozheng Dou, et al. Evolution of a 4-Benzyloxy-benzylamino Chemotype to Provide Efficacious, Potent, and Isoform Selective PPARα Agonists as Leads for Retinal Disorders. J Med Chem. 2020 Mar 26;63 (6) :2854-2876.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARα