PPARγ agonist 20

• Description:

  PPARγ agonist 20 is a potent, orally active PPAR-γ agonist. PPARγ agonist 20 effectively increases antioxidant defenses (SOD, GSH) and reduces lipid peroxidation. PPARγ agonist 20 can upregulate of Pparg, Glut4, and AdipoQ, suppresses of TNF-α, IL-6, and NF-κB p65. PPARγ agonist 20 significantly lowers fasting blood glucose, improving glucose tolerance, and restoring metabolic balance in Streptozotocin (HY-13753) -Nicotinamide (HY-B0150) -induced diabetic rats. PPARγ agonist 20 can be used for the study of type 2 diabetes[1].

• UNSPSC:

  12352005

• Target:

  Glutathione Peroxidase; Interleukin Related; NF-κB; PPAR; SOD; TNF Receptor

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Infection; Endocrinology; Metabolic Disease

• Smiles:

  COC1=CC(/C=N/NC(N/N=C/C2=CC=C(C(O)=C2O)O)=S)=CC=C1OC3=CC=NC4=CC(Cl)=CC=C43

• Molecular Formula:

  C25H20ClN5O5S

• Molecular Weight:

  537.97

• References & Citations:

  [1]Pravin NJ, et al. Modulating glucose homeostasis via expression of PPAR-γ TF: Pharmacological insights into quinolone-based hydrazones. Eur J Med Chem. 2025 Dec 15;300:118168.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported