PPARγ agonist 20

CAT: 0804-HY-178447Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178447Size:1 Each
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Description
PPARγ agonist 20 is a potent, orally active PPAR-γ agonist. PPARγ agonist 20 effectively increases antioxidant defenses (SOD, GSH) and reduces lipid peroxidation. PPARγ agonist 20 can upregulate of Pparg, Glut4, and AdipoQ, suppresses of TNF-α, IL-6, and NF-κB p65. PPARγ agonist 20 significantly lowers fasting blood glucose, improving glucose tolerance, and restoring metabolic balance in Streptozotocin (HY-13753) -Nicotinamide (HY-B0150) -induced diabetic rats. PPARγ agonist 20 can be used for the study of type 2 diabetes[1].
UNSPSC
12352005
Target
Glutathione Peroxidase; Interleukin Related; NF-κB; PPAR; SOD; TNF Receptor
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Field of Research
Infection; Endocrinology; Metabolic Disease
Smiles
COC1=CC(/C=N/NC(N/N=C/C2=CC=C(C(O)=C2O)O)=S)=CC=C1OC3=CC=NC4=CC(Cl)=CC=C43
Molecular Formula
C25H20ClN5O5S
Molecular Weight
537.97
References & Citations
[1]Pravin NJ, et al. Modulating glucose homeostasis via expression of PPAR-γ TF: Pharmacological insights into quinolone-based hydrazones. Eur J Med Chem. 2025 Dec 15;300:118168.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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