PPARα agonist 4

• Description :

  PPARα agonist 4 (compound BH400) is a PPARα agonist (EC50= 1.2 μM) . PPARα agonist 4 also inhibits STING (IC50: 8.1 μM) . PPARα agonist 4 reduces the CoCl2-induced production of ROS and LPS-induced secretion of IL-6. The PPARα agonist 4 restores the decreased expression of PCG1α induced by LPS[1].

• UNSPSC :

  12352005

• Target :

  PPAR; Reactive Oxygen Species (ROS) ; STING

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/pparα-agonist-4.html

• Smiles :

  O=C(O)C1=CC(NCC2=CC=C(C3=CC=C(F)C=C3)C=C2)=CC=C1O

• Molecular Formula :

  C20H16FNO3

• Molecular Weight :

  337.34

• References & Citations :

  [1]Bo Hu, et al. Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators. ACS Medicinal Chemistry Letters Article ASAP

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported