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PPARα agonist 4

CAT: 0804-HY-159146Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-159146Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PPARα agonist 4 (compound BH400) is a PPARα agonist (EC50= 1.2 μM) . PPARα agonist 4 also inhibits STING (IC50: 8.1 μM) . PPARα agonist 4 reduces the CoCl2-induced production of ROS and LPS-induced secretion of IL-6. The PPARα agonist 4 restores the decreased expression of PCG1α induced by LPS[1].
UNSPSC
12352005
Target
PPAR; Reactive Oxygen Species (ROS) ; STING
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pparα-agonist-4.html
Smiles
O=C(O)C1=CC(NCC2=CC=C(C3=CC=C(F)C=C3)C=C2)=CC=C1O
Molecular Formula
C20H16FNO3
Molecular Weight
337.34
References & Citations
[1]Bo Hu, et al. Design and Assessment of First-Generation Heterobifunctional PPARα/STING Modulators. ACS Medicinal Chemistry Letters Article ASAP
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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