Keap1-Nrf2-IN-3

Keap1-Nrf2-IN-3

• CAS Number: 2095066-47-8
• UNSPSC Description: Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a Kd value of 2.5 nM for KEAP1 protein.
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: Cancer-programmed cell death
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C([C@H]2[C@H](C3=CN(C)N=N3)C2)N(C4=CC=CC(C5=CC=CC(C(N6[C@H](CCC)CCCC6)=O)=C5)=C4)N=C1)O
• Molecular Weight: 538.64
• References & Citations: [1]Norton D, et al. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):15949-15972.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported