Keap1-Nrf2-IN-3

• UNSPSC Description:

  Keap1-Nrf2-IN-3 is a KEAP1:NRF2 protein−protein interaction inhibitor, and with a Kd value of 2.5 nM for KEAP1 protein.

• Target Antigen:

  Keap1-Nrf2

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C([C@H]2[C@H](C3=CN(C)N=N3)C2)N(C4=CC=CC(C5=CC=CC(C(N6[C@H](CCC)CCCC6)=O)=C5)=C4)N=C1)O

• Molecular Weight:

  538.64

• References & Citations:

  [1]Norton D, et al. Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J Med Chem. 2021 Nov 11;64(21):15949-15972.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2095066-47-8