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ER-27319

CAT: 0804-HY-138961Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-138961Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ER-27319, an acridone derivative, is a potent and selective SYK inhibitor, and inhibits the tyrosine phosphorylation of SYK and its activity. ER-27319 inhibits the release of antigen-induced allergic mediators from human and rat mast cells with an IC50 of 10 μM and can be used for study in allergic diseases[1][2].
CAS Number
201010-95-9
UNSPSC
12352005
Hazard Statement
H302+H312
Target
Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/er-27319.html
Purity
98.66
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2)N(CCCN)C3=C(C)C(C)=CC=C13.O=C(O)C(O)=O
Molecular Formula
C20H22N2O5
Molecular Weight
370.40
Precautions
H302+H312
References & Citations
[1] Katsuhiro Moriya, et al. ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk. Proc Natl Acad Sci U S A. 1997 Nov 11; 94 (23) : 12539–12544.|[2]Yoshitaka Sato, et al. IgG-mediated signal transduction in canine mastocytoma-derived cells. Int Arch Allergy Immunol. 2002 Dec;129 (4) :305-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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